Adjunct mifepristone for cervical preparation prior to dilation and evacuation: a randomized trial
This non-inferiority trial compared the procedure times between two groups of women undergoing second trimester surgical abortions. The first group was given one set of osmotic dilators plus mifepristone the day prior to the procedure, while the second group was given two sets of osmotic dilators. Both groups received misoprostol prior to undergoing the procedure. Mifepristone with one set of osmotic dilators and misoprostol did not result in longer procedure times or less cervical dilation than serial (two sets) of osmotic dilators and misoprostol, and has the potential to improve access to second trimester abortion without compromising safety.
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