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Are two doses of misoprostol after mifepristone for early abortion better than one?

This article reports on a study to determine if a repeat dose of misoprostol following mifepristone or a single dose of misoprostol increases the efficacy of medical termination of pregnancy. Women were randomised to receive one or two doses of 400 microgram oral misoprostol at the clinic 48 hours after administration of 200 mg mifepristone. While an additional oral dose of 400 microgram misoprostol did not significantly increase the rate of complete abortion without surgical intervention, the additional dose did significantly reduce the rate of continuing pregnancies without compromising the acceptability and ease of use of the method.

Access the full text at the following link British Journal of Obstetrics and Gynaecology, (Mar 2007), 114(3): 271–8.

  • Topic: Medical Abortion
  • Type: Staff Publication
  • Author: Coyaji, K., Krishna, U., Ambardekar, S., Bracken, H., Raote, V., Mandlekar, A., Winikoff, B.
  • Published: March 2007