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Continuing pregnancy after mifepristone and "reversal" of first-trimester medical abortion: A systematic review

In early 2015, legislatures in Arizona and Arkansas passed laws requiring physicians providing abortion to inform women that if they choose to have a medical abortion, and decide not to complete the abortion, the effect of mifepristone may be reversed with specific treatment. This systemic literature review looks at the effectiveness of medical abortion “reversal” treatment. Only 1 study met the inclusion criteria for abortion reversal, and 13 studies met criteria for continuing pregnancy after mifepristone alone. The study that looked at reversing the effects of mifepristone was of poor quality and with few details: the mifepristone dosage was not noted, and only six patients had follow-up data. From the dearth of literature surrounding this topic, it is clear that there is insufficient evidence in the literature to determine whether treatment with progesterone after mifepristone results in a higher proportion of continuing pregnancies as compared to expectant management.

Access the abstract.

  • Topic: Medical Abortion
  • Type: Staff Publication
  • Author: Grossman, D., White, K., Harris, L., Reeves, M., Blumenthal, P.D., Winikoff, B., Grimes, D.A.
  • Published: September 2015