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Cervical Preparation Before Dilation and Evacuation Using Adjunctive Misoprostol or Mifepristone Com

Published:
Nov. 2015
Type:
Staff Publication
Topic:
Medical Abortion
Authors:
Winikoff, Beverly Goldberg, A.B., Fortin, J.A., Drey, E.A., Dean, G., Lichtenberg, E.S., Bednarek, P.H., Chen, B.A., Dutton, C., McKetta, S., Maur

This double-blind, three-arm, multicenter, randomized trial compared overnight osmotic dilators alone, dilators plus 400 micrograms buccal misoprostol 3 hours preoperatively, and dilators plus 200 mg oral mifepristone during dilator placement for dilation and evacuation for second trimester abortion. Despite no difference in operative time, adjunctive mifepristone facilitates later dilation and evacuation compared with osmoticdilators alone and is better tolerated than misoprostol.

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