This review examined ten randomized clinical trials comparing interventions for the treatment of primary postpartum haemorrhage (PPH), one of the top five causes of maternal mortality. Oxytocin infusion was found to be more effective and cause fewer side effects than misoprostol as a first line of treatment, although the two were similar when used after prophylactic uterotonics. The authors also explore the limitations of the studies reviewed and suggest direction for future studies on PPH treatment.
Cochrane Database Syst Rev. 2014 Feb 13;2:CD003249. doi: 10.1002/14651858.CD003249.pub3.
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