Efficacy and acceptability of a mifepristone-misoprostol combined regimen for early induced abortion among women in Mexico City
- June 4th, 2014
- Medical Abortion
- Peña, M., Dzuba, I.G., Smith, P.S., Mendoza, L.J., Bousiéguez, M., Martínez, M.L., Polanco, R.R., Villalón, A.E., Winikoff, B.
Int J Gynaecol Obstet; 2014 Oct; 127(1):82-5; doi:10.1016/j.ijgo.2014.04.012
Objective: To evaluate the experience of women receiving mifepristone-misoprostol for early induced abortion in public sector facilities in the Federal District of Mexico City.
Methods: An open-label prospective study was conducted with 1000 pregnant women who sought induced abortion with a pregnancy of up to 63days of gestation, as measured from the date of their last menstrual period. The study was conducted in three public sector healthcare facilities: two secondary level hospitals and one primary care clinic. Women ingested 200mg mifepristone on day 1, followed by 800μg buccal misoprostol 24hours later, and they returned for follow-up on day 8. The primary outcome was complete abortion without recourse to surgical intervention.
Results: A total of 971 women received mifepristone-misoprostol and were included in the analysis for efficacy of treatment. The overall efficacy of the combined medical abortion regimen studied was 97.3% (n=945); the success rate did not vary significantly by gestational age (95.9%-100%; P=0.449). Most women (n=922, 95.0%) had a successful induced abortion with only one dose of misoprostol.
Conclusion: The combined mifepristone and buccal misoprostol regimen was found to be highly effective and acceptable among Mexican women.