Jill Durocher

Research Summary: Gynuity Health Projects Evaluates a Letrozole Plus Misoprostol Regimen for Medication Abortion

December 20th, 2022
Research Summary
Medication Abortion
Gynuity Health Projects

This resource, available in English and Spanish, summarizes the key findings from a small pilot study by Gynuity Health Projects and the University of Utah undertaken to explore the efficacy and safety of a single dose of letrozole plus misoprostol regimen for medication abortion.

Letrozole is traditionally used for treating breast cancer and infertility. This low cost and accessible medication available in tablet form has been identified as a potential alternative abortifacient that, in the absence of mifepristone and when taken in combination with misoprostol, could improve upon the efficacy of a misoprostol-only medication abortion regimen.

Journal Article (open access) Tara Shochet, David Turok, Laura J. Frye, Corinne D. Sexsmith, Lori M. Gawron, Jennifer E. Kaiser, Beverly Winikoff, Single dose letrozole and misoprostol for termination of pregnancy through 63 days’ gestation: A pilot study, Contraception (2022), doi: