Jill Durocher

Misoprostol in Addition to Routine Treatment of Postpartum Hemorrhage: A Hospital-Based Randomized-Controlled Trial in Karachi, Pakistan

August 21st, 2008
Postpartum Hemorrhage
Zuberi, N.F., Durocher, J., Sikander, R., Baber, N., Blum, J., Walraven, G.

BMC Pregnancy Childbirth; 2008 Aug 21; 8:40; doi:10.1016/j.ijgo.2007.09.008

Postpartum hemorrhage (PPH) remains a major killer of women worldwide. Standard uterotonic treatments used to control postpartum bleeding do not always work and are not always available. Misoprostol's potential as a treatment option for PPH is increasingly known, but its use remains ad hoc and available evidence does not support the safety or efficacy of one particular regimen. This study aimed to determine the adjunct benefit of misoprostol when combined with standard oxytocics for PPH treatment. The study concluded that a 600 mcg dose of misoprostol given sublingually shows promise as an adjunct treatment for PPH and its use should continue to be explored for its life-saving potential in the care of women experiencing PPH.