Misoprostol-induced fever and genetic polymorphisms in drug transporters
- Published
- June 30th, 2015
- Type
- Staff Publication
- Topic
- Postpartum Hemorrhage
- Authors
- Winikoff, Beverly, Durocher, Jill, Alfirevic, A., Elati, A., León, W., Dickens, D., Rädisch, S., Box, H., Siccardi, M., Curley, P., Xinarianos, G., A
Aim:
Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic susceptibility may play a role in misoprostol-induced fever.
Subjects & methods:
Body temperature of women treated with misoprostol for termination of pregnancy in the UK (n = 107) and for postpartum hemorrhage in Ecuador (n = 50) was measured. Genotyping for 33 single nucleotide polymorphisms in 15 candidate genes was performed. Additionally, we investigated the transport of radiolabeled misoprostol acid across biological membranes in vitro.
Results:
The ABCC4 single nucleotide polymorphism rs11568658 was associated with misoprostol-induced fever. Misoprostol acid was transported across a blood-brain barrier model by MRP4 and SLCO1B1.
Conclusion:
Genetic variability in ABCC4 may contribute to misoprostol-induced fever in pregnant women. Original submitted 21 January 2015; Revision submitted 24 April 2015.
Access the abstract.