Off-Label Indications for Mifepristone in Gynecology and Obstetrics

Contraception; 2015 Sep; 92(3):203-5; doi:10.1016/j.contraception.2015.06.021

This article examines the off-label uses of mifepristone, and describes how it can be used to treat a variety of reproductive health issues. Currently, mifepristone is only approved to induce abortions during the first trimester. However, it is regularly used to help manage second trimester terminations. Research has shown that mifepristone can also be used to help prime the cervix for labor at term. While it is common practice to use other medications off-label, access to mifepristone in the United States has been severely limited by states’ mandates that mifepristone be used strictly in accordance with the label.